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目的:观察美施康定联合硬膜外阻滞用于提高晚期癌症患者生活质量、镇痛的有效性。方法:选择2013年6月至2015年6月广州新海医院诊断为晚期癌症的50例患者,采用双盲法将患者分为对照、治疗两组,每组25例。对照组常规治疗,治疗组硬膜外注射美施康定进行阻滞治疗,统计不良反应,对患者疼痛、生活质量改善情况进行评估。结果:治疗组不良反应率为16.0%,明显低于对照组36.0%,治疗组不良反应少,差异具有统计学意义(P<0.05)。结论:临床对于晚期癌痛患者,使用硬膜外阻滞联合美施康定治疗,不仅能有效缓解患者疼痛、提高其生活质量,且不良反应少。
OBJECTIVE: To observe the effectiveness of combined use of Meishi Kangding and epidural blockade in improving the quality of life and analgesia in patients with advanced cancer. Methods: Fifty patients diagnosed with advanced cancer in Guangzhou Xinhai Hospital from June 2013 to June 2015 were enrolled. Patients were divided into two groups according to a double-blind method. Two groups were treated with 25 patients in each group. In the control group, the patients in the treatment group were treated with epidural injection of Melatonin for blocking therapy, and the adverse reaction was counted to evaluate the patient’s pain and quality of life improvement. Results: The adverse reaction rate in the treatment group was 16.0%, which was significantly lower than that in the control group (36.0%). There was little adverse reaction in the treatment group. The difference was statistically significant (P <0.05). Conclusion: The clinical application of epidural block combined with Meishen Kangding in patients with advanced cancer pain not only can effectively relieve pain and improve the quality of life of patients with less adverse reactions.