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目的:研究血管内皮细胞生长因子在颊癌中的表达,探讨其与颊癌的发生、发展的关系。方法:采用免疫组织化学S-P法检测40例颊癌组织、30例癌旁组织、10例正常颊黏膜组织中血管内皮细胞生长因子(VEGF)表达水平的变化。结果:颊癌组织、癌旁组织和正常颊黏膜组织中的VEGF表达率分别为85.0%、26.7%、10.0%,经统计学处理三者表达率比较差异有显著性(χ2=32.26,P<0.01);随着病理分级的升高,VEGF阳性表达强度增高,与病理分级呈正相关(rs=0.672,P<0.001);随着临床分期的升高,VEGF阳性强度增强,与临床分期呈正相关(rs=0.493,P<0.01)。结论:VEGF在颊癌发生、发展、浸润及转移中具有重要的作用,可作为一种有价值的标志物。
Objective: To investigate the expression of vascular endothelial growth factor in buccal carcinoma and its relationship with the occurrence and development of buccal carcinoma. Methods: The expression of vascular endothelial growth factor (VEGF) in 40 cases of buccal carcinoma tissues, 30 cases of paracancerous tissues and 10 cases of normal buccal mucosa tissues were detected by immunohistochemical S-P method. Results: The expression rates of VEGF in cheek cancer tissues, paracancerous tissues and normal buccal mucosa tissues were 85.0%, 26.7% and 10.0%, respectively. There was significant difference in the expression rates of VEGF between the three groups (χ2 = 32.26, P < 0.01). The positive expression of VEGF increased with the increase of pathological grade, which was positively correlated with the pathological grade (rs = 0.672, P <0.001). With the increase of clinical stage, the positive expression of VEGF was positively correlated with clinical stage (rs = 0.493, P <0.01). Conclusion: VEGF plays an important role in the occurrence, development, infiltration and metastasis of buccal carcinoma and may serve as a valuable marker.