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目的:观察促孕汤与阿司匹林联合对克罗米芬(CC)促排卵周期子宫内膜发育、黄体功能及临床妊娠率的影响。方法:对2007年1月～2010年1月荆门市第二人民医院60例排卵障碍的患者随机分为克罗米芬组(Ⅰ组),克罗米芬+阿司匹林组(Ⅱ组),克罗米芬+阿司匹林+促孕汤(Ⅲ组),每组20例,观察3组患者HCG日和排卵后7天子宫内膜厚度、子宫动脉搏动指数(PI)、子宫动脉血流阻力指数(RI),排卵后7天孕酮水平和临床妊娠率。结果:Ⅱ组和Ⅲ组HCG日和排卵后7天子宫内膜厚度显著高于Ⅰ组,但PI和RI低于Ⅰ组。Ⅲ组排卵后7天孕酮水平、临床妊娠率显著高于Ⅰ组和Ⅱ组。结论:促孕汤与阿司匹林联合应用可以改善克罗米芬促排卵引起的子宫内膜发育不良,提高孕酮水平,有助于提高临床妊娠率。
OBJECTIVE: To observe the effect of progestational soup combined with aspirin on endometrial development, luteal function and clinical pregnancy rate in clomiphene citrate (CC) -activated ovarian cycles. Methods: 60 patients with ovulation disorder in Jingmen Second People’s Hospital from January 2007 to January 2010 were randomly divided into clomiphene citrate group (group Ⅰ), clomiphene citrate and aspirin group (group Ⅱ), clomiphene citrate + aspirin + (Group Ⅲ), 20 cases in each group. The endometrial thickness, uterine arterial pulse index (PI), uterine artery blood flow resistance index (RI) and ovulation 7 Day progesterone levels and clinical pregnancy rates. Results: The endometrial thickness of HCG group and 7 days after ovulation in group Ⅱ and group Ⅲ were significantly higher than those in group Ⅰ, but PI and RI were lower than those in group Ⅰ. The level of progesterone in group Ⅲ after 7 days of ovulation was significantly higher than that in group Ⅰ and Ⅱ. Conclusion: The combination of promoting pregnancy soup and aspirin can improve clomiphene induced ovulation induced endometrial dysplasia, increase progesterone levels, help to improve the clinical pregnancy rate.