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目的分析血尿酸水平对男性人群脑出血发病的影响。方法采用队列研究方法,以成年男性76 183人作为观察队列,按2006-2007年首次健康查体时的血尿酸四分位水平分组,平均随访4.04年,用Cox风险比例回归模型分析血尿酸对脑出血发病的影响。结果在血尿酸最高四分位组,研究对象的年龄较大,收缩压、体质量指数、总胆固醇、三酰甘油水平较高,空腹血糖水平较低,高血压、糖尿病和高血脂症病史及每天吸烟、饮酒比例较高。血尿酸四分位组(从低到高)的脑出血累积发病率分别为0.47%、0.46%、0.44%、0.72%。单因素Cox比例风险回归模型分析显示,血尿酸四分位组(从低到高)发生脑出血的HR(95%CI)分别为1.064(0.782～1.446)、1.010(0.740～1.378)、1.000(参照)、1.539(1.159～2.044);多因素Cox风险比例回归模型校正年龄、血压、血糖、血脂及主要病史、吸烟、饮酒等因素后显示,血尿酸四分位组脑出血的HR(95%CI)分别为1.043(0.756～1.439)、1.021(0.743～1.403)、1.000(参照)、1.393(1.041～1.863)。结论高血尿酸是男性脑出血的危险因素。
Objective To analyze the effect of serum uric acid level on the incidence of cerebral hemorrhage in male population. Methods A cohort study was conducted with 76 183 adult males as observational cohorts, grouped according to the level of uric acid and uric acid during the first physical examination in 2006-2007. The patients were followed up for a mean of 4.04 years. Cox proportional hazards model was used to analyze the serum uric acid The impact of cerebral hemorrhage. Results In the highest quartile of serum uric acid, the study subjects were older, systolic blood pressure, body mass index, total cholesterol, triglyceride levels higher, lower fasting blood glucose levels, history of hypertension, diabetes and hyperlipidemia Daily smoking, drinking a higher proportion. The cumulative incidence of cerebral hemorrhage in the uric acid quartiles (from low to high) was 0.47%, 0.46%, 0.44%, 0.72%, respectively. Univariate Cox proportional hazards regression model analysis showed that the HR (95% CI) of cerebral hemorrhage in the uric acid tertile group were 1.064 (0.782-1.446), 1.010 (0.740-1.378) and 1.000 ( (1.595, 1.159 and 2.044 respectively). After adjusting for age, blood pressure, blood glucose, blood lipid, main medical history, smoking and alcohol consumption, the multivariate Cox proportional hazards regression model showed that HR (95% CI) were 1.043 (0.756-1.439), 1.021 (0.743-1.403), 1.000 (reference), 1.393 (1.041-1.863), respectively. Conclusion Hyperuricemia is a risk factor for cerebral hemorrhage in men.