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目的探讨代谢综合征患者空腹血清胰岛素样生长因子-1和高敏C反应蛋白与MS的关系。方法观察组为笔者所在医院门诊2012年2月～2012年8月收治的45例MS患者,对他们身高、体重、腰围、臀围、血压、空腹血糖、血脂及相关资料进行收集,对体重指数、腰臀比进行计算,并对血清IGF-1和hs-CRP浓度进行测定,对照组则选取健康体检者27例。结果观察组与和照组相比,血清hs-CRP的浓度升高,差异有统计学意义(P<0.01)。而血清IGF-1浓度降低,差异有统计学意义(P<0.05)。血清IGF-1和hs-CRP水平呈负相关。在观察组中,IGF-1的影响因素可能是LDL-C、hs-CRP;在对照组中,只有hs-CRP可能是IGF-1的影响因素。结论观察组患者存在低度慢性炎症,低IGF-1浓度与高hs-CRP水平提示了代谢综合征的一些可能的病理生理机制。
Objective To investigate the relationship between fasting serum insulin-like growth factor-1 and high-sensitivity C-reactive protein and MS in patients with metabolic syndrome. Methods The observation group was 45 MS patients admitted to the hospital outpatient department from February 2012 to August 2012 with their height, weight, waist circumference, hip circumference, blood pressure, fasting blood glucose, blood lipids and related data collected. The body mass index , Waist-hip ratio were calculated, and serum IGF-1 and hs-CRP concentrations were measured in the control group were selected healthy subjects in 27 cases. Results Compared with the control group, the concentration of hs-CRP in the observation group was significantly increased (P <0.01). However, the serum IGF-1 level decreased, the difference was statistically significant (P <0.05). Serum IGF-1 and hs-CRP levels were negatively correlated. In the observation group, the influencing factors of IGF-1 may be LDL-C, hs-CRP; in the control group, only hs-CRP may be the influencing factor of IGF-1. Conclusions The patients in observation group have low chronic inflammation. Low IGF-1 concentration and high hs-CRP level suggest some possible pathophysiological mechanisms of metabolic syndrome.