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目的 探讨促炎细胞因子和抗炎细胞因子在自发性腹膜炎 (SBP)血清和腹水中的表达及其相互作用的结果。方法 采用ELISA法检测 30例SBP、18例肝硬化腹水患者血清和腹水中促炎细胞因子 (IL - 1β ,TNF -α ,IL - 6和IL - 8)和抗炎细胞因子 (IL - 10 ,IL - 1ra)。结果 SBP和肝硬化腹水患者两类细胞因子(以IL - 6和IL - 10为代表 )均升高 ,SBP患者升高幅度更明显 ,SBP患者经药物治疗后细胞因子很快下降。结论 促炎细胞因子和抗炎细胞因子在SBP的发生发展过程中均具有重要作用 ,两类细胞因子的动态平衡影响疾病的预后。
Objective To investigate the expression of proinflammatory cytokines and anti-inflammatory cytokines in serum and ascites of spontaneous peritonitis (SBP) and their interaction. Methods Serum and ascitic fluids were collected from 30 patients with SBP and 18 patients with cirrhosis and ascites by ELISA. The levels of pro - inflammatory cytokines (IL - 1β, TNF - α, IL - 6 and IL - 8) and anti - inflammatory cytokines IL - 1ra). Results There were two types of cytokines (represented by IL - 6 and IL - 10) in patients with SBP and cirrhosis and ascites. The increase in SBP patients was more obvious. The cytokines decreased rapidly in patients with SBP after drug treatment. Conclusions Proinflammatory cytokines and anti-inflammatory cytokines play an important role in the development of SBP. The dynamic balance between the two cytokines affects the prognosis of the disease.