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目的探讨地诺前列酮栓用于足月妊娠引产的临床效果及安全性。方法将本院2011年1月-12月240例单胎头位无引产禁忌症的足月孕妇随机分为研究组和对照组各120例,研究组采用阴道后穹窿横置一枚地诺前列酮栓;对照组采用缩宫素静脉点滴。观察两组孕妇用药后宫颈Bishop评分变化、用药至临产时间、临产至分娩时间、分娩方式、胎儿宫内情况、新生儿评分、产后出血等指标。结果两组在促宫颈成熟、用药至临产时间、临产至分娩时间差异有显著性(P<0.01);两组阴道分娩率差异有统计学意义(P<0.05);在新生儿评分、产后出血两组差异无统计学意义。结论地诺前列酮栓用于足月妊娠引产安全有效,可以显著提高宫颈Bishop评分,用于促宫颈成熟及诱发宫缩明显优于缩宫素,能有效降低剖宫产率,促进自然分娩。
Objective To investigate the clinical effect and safety of dinoprostone suppository for induced abortion in full-term pregnancy. Methods A total of 240 full-term pregnant women without contraindications of single fetus from January 2011 to December 2011 in our hospital were randomly divided into study group and control group, with 120 cases in each group. The study group used transvaginal posterior fornix Ketone plug; control group using oxytocin intravenous drip. The changes of cervical Bishop score, medication time to delivery, labor to delivery time, mode of delivery, intrauterine conditions, neonatal score and postpartum hemorrhage were observed in two groups of pregnant women. Results There was significant difference between the two groups in the promotion of cervical ripening, the time from administration to labor, and the time from labor to delivery (P <0.01). There was significant difference in vaginal delivery between the two groups (P <0.05) No significant difference between the two groups. Conclusion The use of dinoprost suppository is safe and effective in induction of labor during term pregnancy. It can significantly improve cervical Bishop score, promote cervix maturation and induce uterine contractions significantly better than oxytocin, which can effectively reduce cesarean section rate and promote natural childbirth.