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提出了一种改性方法以降低水杨酸的生物毒性。以环氧氯丙烷为反应原料和反应溶剂,在60℃条件下,与水杨酸羧基保护产物搅拌醚化反应5h,获得中间产物,通过去羧基保护反应,得到目标化合物。通过对反应最佳条件的探讨,获得目标化合物的收率为76.3%。同时,目标化合物采用傅里叶变换红外光谱进行结构表征。此研究为水杨酸的改性提供了一种新的方法,将促进水杨酸在医学领域上的应用。
A modified method was proposed to reduce the biological toxicity of salicylic acid. Epichlorohydrin as reaction material and reaction solvent, under the condition of 60 ° C, and the salicylic acid carboxylate reaction product was stirred for 5h to obtain the intermediate product, and the target compound was obtained through the decarboxylation protection reaction. Through the discussion of the optimum reaction conditions, the yield of the target compound was 76.3%. At the same time, the target compounds were characterized by Fourier transform infrared spectroscopy. This study provides a new method for the modification of salicylic acid and will promote the application of salicylic acid in the medical field.