目的 :评价国产厄贝沙坦的降压疗效及安全性。方法 :选取 1～ 2级原发性高血压患者 62例 ,随机单盲分为两组 ,厄贝沙坦组 3 2例 ,剂量 15 0～ 3 0 0mg ,1次 /d口服 ;贝那普利对照组 3 0例 ,剂量 10～ 2 0mg/d ,1次 /d口服。必要时均加氢氯噻嗪 12 5～2 5mg/d。观察治疗 4周及 8周末降压疗效、动态血压变化及不良反应。结果 :两组治疗 4周及 8周后显效率分别为 60 %、5 1%及62 %、5 4%;总有效率分别为 74%、70 %及 76%、72 %,组间无显著性差异。厄贝沙坦组治疗 8周后 2 4h血压监测收缩压及舒张压降压谷一峰比值分别为 74%及 70 %。结论 :国产厄贝沙坦治疗 1～ 2级原发性高血压效果持久、稳定 ,耐受性好 ,干咳副作用明显少于贝那普利 Objective: To evaluate the antihypertensive efficacy and safety of domestic irbesartan. Methods: A total of 62 patients with primary or secondary hypertension were randomly divided into two groups randomly. The patients were treated with irbesartan (n = 32) at a dose of 15 0 ~ 300 mg once a day. The control group 30 cases, the dose of 10 ~ 20mg / d, 1 / d orally. Hydrochlorothiazide 125 ~ 25mg / d when necessary. The curative effect, ambulatory blood pressure and adverse reactions at 4 and 8 weeks after treatment were observed. Results: The effective rates were 60%, 51% and 62%, 54% respectively after 4 weeks and 8 weeks of treatment. The total effective rates were 74%, 70%, 76% and 72% respectively. There was no significant difference between the two groups . Irbesartan group 8 weeks after treatment 24 hours blood pressure monitoring systolic blood pressure and diastolic blood pressure valleys peak-to-peak ratio were 74% and 70%. Conclusion: The domestic irbesartan treatment of grade 1 or 2 essential hypertension with long-lasting, stable, well tolerated, dry cough side effects were significantly lower than that of benazepril