目的观察老年肺癌患者血清甘油三酯(TG)与神经元特异性烯醇化酶(NSE)的水平,并分析其相关性,探讨其在老年肺癌患者的筛查、诊断、治疗及预后评估的临床意义。方法选择2015年4月至2016年6月华北理工大学附属医院呼吸内科及心胸外科收治的门诊及住院的老年肺癌患者202例(肺癌组),按照入组前是否进行过化疗,分为未化疗组(94例)和化疗组(108例)。另选择门诊老年人健康体检者80例设为正常对照组。比较各组的血清TG、NSE水平,并分析其相关性。结果肺癌组血清NSE水平高于对照组(P<0.01),TG水平与对照组比较差异无统计学意义(P>0.05);肺癌未化疗组血清TG、NSE水平与肺癌化疗组比较差异均无统计学意义(P均>0.05);肺癌未化疗组及肺癌化疗组血清NSE水平均高于对照组(P<0.05,P<0.01),血清TG水平与对照组比较差异无统计学意义(P>0.05);不同病理类型肺癌患者血清TG水平比较差异无统计学意义(P>0.05),但血清NSE水平各类型间比较差异有统计学意义(P<0.05),其中小细胞癌NSE水平较高;不同病理分期肺癌患者血清TG、NSE水平比较差异无统计学意义(P均>0.05)。未化疗组肺癌血清TG与NSE呈正相关(r=0.138,P=0.046)。结论肺癌患者血清NSE水平升高,血清TG与NSE之间具有相关性,其相关性可能会成为肺癌早期筛查、早期诊断、疗效评价及预后康复评估的一项重要的辅助临床指标。 Objective To observe the serum levels of triglyceride (TG) and neuron-specific enolase (NSE) in elderly patients with lung cancer, and analyze their correlations, and explore the clinical application of screening, diagnosis, treatment and prognosis assessment in elderly lung cancer patients. significance. Methods A total of 202 lung cancer patients (patients with lung cancer) were enrolled in the Department of Respiratory Medicine and Department of Cardiothoracic Surgery at the Affiliated Hospital of North China University of Technology from April 2015 to June 2016. They were divided into non-chemotherapy groups according to whether they had undergone chemotherapy prior to enrollment. Group (94 cases) and chemotherapy group (108 cases). Another 80 outpatients selected for physical examination in the elderly were set as normal controls. The levels of serum TG and NSE in each group were compared and the correlation was analyzed. Results Serum NSE levels in the lung cancer group were higher than those in the control group (P<0.01). There was no significant difference in TG level between the lung cancer group and the control group (P>0.05). There was no difference between the levels of serum TG and NSE in the lung cancer non-chemotherapy group and the lung cancer chemotherapy group. Statistical significance (P>0.05); Serum NSE levels in non-chemotherapy and lung cancer chemotherapy groups were higher than those in the control group (P<0.05, P<0.01), and serum TG levels were not statistically different from those in the control group (P). >0.05); There is no significant difference in serum TG levels between different pathological types of lung cancer patients (P>0.05), but there is a statistically significant difference in serum NSE levels (P<0.05), among which NSE levels of small cell carcinoma are There was no significant difference in the levels of serum TG and NSE in lung cancer patients with different pathological stages (P>0.05). There was a positive correlation between serum TG and NSE in non-chemotherapy patients (r=0.138, P=0.046). Conclusion The serum NSE levels in patients with lung cancer are elevated, and there is a correlation between serum TG and NSE. The correlation may be an important auxiliary clinical indicator for early screening, early diagnosis, curative effect evaluation and prognosis evaluation of lung cancer.