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免疫检查点抑制剂应用作为一种新型的抗肿瘤疗法,是恶性肿瘤治疗史上一个里程碑式的创新。研究发现,抑制免疫检查点对胃肠肿瘤的治疗也十分有效。为了提高免疫治疗的疗效,一些不同的治疗方案正在研究评估中。本文总结了2014年欧洲癌症研究与治疗组织(European Organization for Research and Treatment of Cancer,EORTC)召开的胃肠道肿瘤转化研究会议和近两年美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)年会的相关讨论内容,并从免疫细胞浸润与新分子靶点、免疫检查点抑制剂、免疫治疗遗传标志、免疫检查点抑制剂与溶瘤病毒组合以及个体化免疫治疗这5个方面对胃肠肿瘤免疫治疗的最新研究进展进行综述。
Application of immune checkpoint inhibitor as a new anti-tumor therapy is a milestone in the history of malignant tumor therapy. The study found that inhibition of immune checkpoints for the treatment of gastrointestinal tumors is also very effective. In order to improve the efficacy of immunotherapy, a number of different treatment options are being evaluated. This article summarizes the 2014 Gastrointestinal Tumor Metastasis Conference held by the European Organization for Research and Treatment of Cancer (EORTC) and the recent two years of the American Society of Clinical Oncology (ASCO) Will be related to the content of the discussion, and from the immune cell infiltration and new molecular targets, immune checkpoint inhibitors, genetic markers of immunotherapy, immune checkpoint inhibitor and oncolytic virus combination and individual immunotherapy in these five aspects of gastrointestinal The latest progress of tumor immunotherapy is reviewed.