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目的 探讨中药健忆液益智抗衰老的作用及其机理。方法 用２１ 月龄大鼠作为衰老模型，６月龄大鼠为青年对照组，应用健忆液进行治疗，检测血 浆皮质醇、血液流变学及脑内单胺类神经递质的含量。结果 健忆液能使老年大 鼠皮质醇含量下降；血液粘度改善；脑组织多巴胺（ＤＡ）、去甲肾上腺素（ＮＥ）、５－羟 吲哚乙酸（５－ＨＩＡＡ）含量升高，５－羟色胺（５－ＨＴ）含量降低，以至５－ＨＴＩＮＥ、 ５ＨＴ／ＤＡ、５ＨＴ／５－ＨＩＡＡ比值降低。给药组与模型组比较差异有显著性（Ｐ＜０．０５）， 而与６月龄组比较差异无显著性。结论 健忆液具有延缓衰老的作用，其抗衰老作 用可能与改善大鼠下丘脑－垂体－肾上腺轴功能衰退和血液流变性有关。
Objective To explore the effect and mechanism of traditional Chinese medicine Jianyi liquid on anti-aging. Methods A 21-month-old rat was used as an aging model, and a 6-month-old rat was a young control group. The patient was treated with Jianyi Liquid to detect plasma cortisol, hemorheology, and monoamine neurotransmitter content in the brain. RESULTS: Jianyi Liquid can reduce the cortisol content of aged rats, improve blood viscosity, and increase the levels of dopamine (DA), norepinephrine (NE) and 5-hydroxyindolacetic acid (5-HIAA) in brain tissue. The serotonin (5-HT) content is reduced such that the 5-HTINE, 5HT/DA, and 5HT/5-HIAA ratios decrease. The difference between the administration group and the model group was significant (P<0.05), but there was no significant difference compared with the 6-month-old group. Conclusion Jianyi liquid has anti-aging effects, and its anti-aging effects may be related to the improvement of hypothalamic-pituitary-adrenal axis dysfunction and hemorheology in rats.