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Skp2是泛素连接酶复合物的底物识别亚基,对正常细胞周期起调控作用,在多数恶性肿瘤中表达增高。研究发现Skp2与消化道恶性肿瘤发生、发展、预后和治疗均有密切关系。文章就Skp2与消化道恶性肿瘤的关系作一综述。
Skp2 is a substrate recognition subunit of ubiquitin ligase complex, regulating the normal cell cycle and increasing in most malignant tumors. The study found that Skp2 and gastrointestinal cancer incidence, development, prognosis and treatment are closely related. The article reviews the relationship between Skp2 and gastrointestinal cancer.