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目的：观察静脉注射常用倍他乐克剂量对冠心病患者左心室脑利钠肽(BNP)水平的影响。方法：在冠状动脉造影的患者中选择10例冠心病组和10例排除冠心病的对照组。静脉注射倍他乐克前、后监测心率和左室舒张末压 (LVEDP)；测定左心室 BNP,比较两组用药前后的变化。结果：冠心病患者 BNP 水平较对照组明显升高(P＜ 0.05)。冠心病组和对照组静脉注射倍他乐克前、后心率差异有显著性(P＜0.05),而 LVEDP 和左室 BNP 水平的差异均无显著性(P＞0.05)。结论：BNP 水平上升提示有冠心病的可能。常用倍他乐克剂量不影响血液动力学时不影响 BNP 水平。
Objective: To observe the effect of intravenous injection of betametazole on the level of left ventricular brain natriuretic peptide (BNP) in patients with coronary heart disease. Methods: Coronary angiography in patients selected 10 cases of coronary heart disease group and 10 cases of coronary heart disease control group. Heart rate and left ventricular end-diastolic pressure (LVEDP) were measured before and after intravenous betaxole. The left ventricular BNP was measured and compared before and after treatment. Results: BNP levels in patients with coronary heart disease were significantly higher than those in the control group (P <0.05). Before and after intravenous injection of Betaloc, there was a significant difference in heart rate between coronary heart disease group and control group (P <0.05), but there was no significant difference between LVEDP and left ventricular BNP level (P> 0.05). Conclusion: The increase of BNP level suggests the possibility of coronary heart disease. Commonly used betametazole dose does not affect hemodynamics does not affect BNP levels.