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目的 :对慢性阻塞性肺气肿与老年性肺气肿的血清α1 -抗胰蛋白酶 (α1 - AT)和肺功能作检测 ,以探讨α1 - AT在肺气肿发病机理中的作用。方法 :选择肺气肿患者 5 0例 (其中慢性阻塞性肺气肿 32例 ,老年性肺气肿 2 8例 )和正常人 2 0例 ,取静脉血用微量比浊法测定 α1 - AT,用肺功能测量仪检测肺功能。结果与结论 :慢性阻塞性肺气肿患者 α1 - AT水平降低 ,而老年性肺气肿患者 α1 - AT变化不明显 ,前者 α1 - AT与 1秒用力呼气量 (FEV1)呈正相关 ,与残气量 (RV)呈负相关 ,说明 α1 - AT降低可能是慢性阻塞性肺气肿形成的原因之一。
Objective: To detect serum α1 - antitrypsin (α1 - AT) and pulmonary function in chronic obstructive pulmonary emphysema and senile emphysema in order to investigate the role of α1 - AT in the pathogenesis of emphysema. Methods: Totally 50 patients with emphysema (32 with chronic obstructive pulmonary emphysema and 28 with senile emphysema) and 20 normal subjects were enrolled in this study. The levels of α1 - AT, Pulmonary function test instrument to detect lung function. RESULTS AND CONCLUSION: The levels of α1 - AT in patients with COPD were decreased, while the changes of α1 - AT in patients with senile emphysema were insignificant. The former α1 - AT was positively correlated with forced expiratory volume in one second (FEV1) Gas volume (RV) was negatively correlated, indicating that α1 - AT decreased may be one of the reasons for the formation of chronic obstructive pulmonary emphysema.