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目的:分析研究盐酸二甲胺四环素在辅助治疗慢性牙周炎不同疗程的治疗效果以及作用分析。方法:选取2009年3月到2011年10月的80例慢性牙周炎患者资料进行回顾性分析,80例患者共有患牙200颗,将80例患者随机分为两组,观察组和对照组各100颗,观察组患者辅助用药盐酸二甲胺四环素,比较两组患者在用药结束之后1周和4周的牙周袋深度和探诊出血以及附着水平等变化。结果:两组患者在用药结束之后1周和4周的牙周袋深度和探诊出血以及附着水平相较基线时都存在明显降低;在用药结束1周的时候观察组患者的牙周袋深度和探诊出血以及附着水平与对照组比较略低,但是没有显著差异(P>0.05),不具有统计学意义;在患者用药结束4周的时候观察组和对照组患者的牙周袋深度和探诊出血以及附着水平比较存在显著差异(P<0.05),具有统计学意义。结论:盐酸二甲胺四环素针对治疗慢性牙周炎存在显著的辅助效果,值得在临床科室中广泛推广使用。
Objective: To analyze the effect of minocycline hydrochloride in adjuvant treatment of chronic periodontitis with different course of treatment. Methods: The data of 80 patients with chronic periodontitis from March 2009 to October 2011 were retrospectively analyzed. The total number of 80 patients was 200, and 80 patients were randomly divided into two groups. The observation group and the control group 100 in each group. Patients in the observation group were assisted with minocycline hydrochloride. Periodontal pocket depth, probing bleeding, and attachment level at 1 and 4 weeks after the end of treatment were compared between the two groups. Results: After 1 week and 4 weeks after the end of medication, the PDL depth, probe bleeding and attachment level of both groups were significantly lower than those at baseline. At the end of 1 week, the PDL depth And exploration of bleeding and attachment levels compared with the control group was slightly lower, but no significant difference (P> 0.05), not statistically significant; at the end of the patient medication 4 weeks when the observation group and the control group patients with periodontal pocket depth and There was significant difference in bleeding and attachment between the two groups (P <0.05), which was statistically significant. CONCLUSION: Minocycline hydrochloride has obvious auxiliary effect in the treatment of chronic periodontitis and deserves to be widely used in clinical departments.