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目的:探讨微卫星不稳定的散发性大肠癌的临床病理特征及微卫星不稳定表型和DNA倍体类型的关系。方法:对71例散发性大肠癌行BAT25和BAT26两个位点的微卫星不稳定检测和流式细胞术倍体分析,探讨微卫星不稳定状态和临床病理特征及DNA倍体类型的关系。结果:微卫星不稳定的阳性率为9.86%(7/71),微卫星不稳定表型和发病部位、组织学类型及分化程度相关(P<0.05),而与性别、年龄、淋巴结转移和分期无关。微卫星不稳定的散发性大肠癌中右半结肠癌和低分化腺癌的比例高于微卫星稳定者。68例患者检出二倍体和异倍体分别为18和50例,微卫星不稳定表型者5例为二倍体,因此和DNA倍体类型显著相关(P=0.012)。结论:微卫星不稳定的散发性大肠癌好发于右半结肠,具有低分化腺癌的倾向,多为二倍体。
OBJECTIVE: To investigate the clinicopathological features, microsatellite instability phenotypes and DNA ploidy types in microsatellite instable sporadic colorectal cancer. Methods: Microsatellite instability and flow cytometry analysis of BAT25 and BAT26 were performed in 71 patients with sporadic colorectal cancer. The relationship between microsatellite instability, clinicopathological features and DNA ploidy types was explored. Results: The positive rate of microsatellite instability was 9.86% (7/71). The microsatellite instability phenotype was associated with the location, histological type and degree of differentiation (P <0.05), but not with gender, age, lymph node metastasis Staging has nothing to do. Microsatellite instability of sporadic colorectal cancer in the right colon cancer and poorly differentiated adenocarcinoma of the proportion of microsatellite stable. 68 patients detected diploid and aneuploid were 18 and 50 cases, microsatellite instability phenotype in 5 cases were diploid and therefore significantly associated with the DNA ploidy type (P = 0.012). Conclusion: Microsatellite instability of sporadic colorectal cancer occurs in the right colon, with poorly differentiated adenocarcinoma, mostly diploid.