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目的了解P53基因在泪腺肿瘤的表达及其临床病理学意义。方法应用免疫组织化学ABC法检测57例泪腺上皮性肿瘤患者和10例正常人泪腺组织中P53蛋白的表达情况，并与病理分级、复发相联系。结果10例正常人泪腺组织中P53表达全部为阴性；恶性肿瘤患者的表达率为48．6％，良性肿瘤中P53达率为18％，二者相比有显著性差异（P＜0．025）；复发患者阳性率为76．9％，明显高于未复发患为31．8％（P＝0．015）。结论P53基因参与了泪腺肿瘤的发生发展并与肿瘤的分化和复发有关。
Objective To investigate the expression of P53 gene in lacrimal gland tumor and its clinicopathological significance. Methods The expression of P53 protein in 57 cases of lacrimal gland epithelial tumor and 10 cases of normal lacrimal gland was detected by immunohistochemical ABC method and correlated with pathological grade and recurrence. Results The expression of P53 was all negative in 10 cases of normal lacrimal gland tissues. The expression rate of P53 was 48.6% in malignant tumors and 18% in benign tumors, the difference was significant (P <0.025 ). The positive rate of recurrence was 76.9%, which was significantly higher than that of non-recurrence (31.8%, P = 0.015). Conclusion P53 gene is involved in the development of lacrimal gland tumors and is related to tumor differentiation and recurrence.