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一些学者通过对有丝分裂原如PHA和刀豆素A(ConA)的刺激所引起的淋巴细胞增殖和IL-2R表达的研究,认为慢性乙型肝炎患者存在细胞免疫功能缺陷.然而,由于检测方法特异性差,不能得出有关慢性乙肝患者T细胞功能状态的确切结论.所以在研究中,通过T细胞活化的两条主要分子途径,观察了慢性乙肝病毒感染者外周血淋巴细胞(PBL)不同活化抗原的表达和增殖应答.研究对象为15例HBsAg持续阳性至少12个月,并行肝活检证实的慢性乙肝病人(CHB),CHB的诊断严格按国际公认的诊断标准.15例病人中9例通过HBV DNA
Some scholars believe that patients with chronic hepatitis B are deficient in cellular immunity due to studies on lymphocyte proliferation and IL-2R expression induced by stimulation of mitogens such as PHA and ConA.However, due to the specificity of the detection method Poor, and can not draw the exact conclusion of the status of T cell function in patients with chronic hepatitis B. Therefore, in the study, T cell activation by two major molecular pathways observed in patients with chronic hepatitis B virus infection of peripheral blood lymphocytes (PBL) different activation antigen (CHB) patients with persistent HBsAg positive for at least 12 months and confirmed by liver biopsy.The diagnostic value of CHB was in accordance with internationally accepted diagnostic criteria.Among the 15 patients, 9 patients were infected with HBV DNA