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实验以β-环糊精和对苯二甲酰氯为原料,合成了一种新型刚性结构的桥联环糊精——1,4-二甲酰胺基苯桥联β-环糊精,并通过1H NMR、红外和紫外以及元素分析等对其结构进行了表征.采用荧光光谱滴定法分别测定了该桥联环糊精与几种具有不同形状和电子密度的染料分子在25℃磷酸缓冲溶液(p H=7.20)中的包结配位稳定常数KS.结果表明,桥联环糊精的键合能力远远增强,桥联环糊精与天然β-环糊精相比,对TNS,ANS,AR,NR和Rh B的包结稳定常数分别提高了3.3,15.3,2.2,12.5和5.8倍.从主-客体间的尺寸匹配关系和多重识别机理等方面探讨了桥联环糊精对客体分子的协同键合作用.
In the experiment, β-cyclodextrin and β-cyclodextrin were synthesized by using β-cyclodextrin and terephthaloyl chloride as raw materials. 1H NMR, IR and UV and elemental analysis were used to characterize the structure.The fluorescence spectrometric titration method was used to determine the interaction between the bridged cyclodextrin and several dye molecules with different shape and electron density at 25 ℃ in phosphate buffer solution p H = 7.20). The results showed that the binding ability of bridged cyclodextrin was much stronger than that of natural β-cyclodextrin. , The entrapment stability constants of AR, NR and Rh B increased by 3.3, 15.3, 2.2, 12.5 and 5.8 times, respectively. The effects of bridged cyclodextrins on the guest Molecular synergistic bonding.