论文部分内容阅读
目的评价早孕期B超引导下经腹绒毛取材组织样本的细胞遗传学分析在产前诊断中的应用价值。方法回顾分析2010年1月到2011年6月42例早孕期产前细胞遗传学诊断的病例资料。结果 42例取材时间9～13周,穿刺成功率100%,培养成功率为97.6%,平均培养时间为10天,发现异常核型4例。结论孕9周后行B超引导经腹绒毛取材是一项安全可行的早孕期介入性产前诊断方法。绒毛细胞长期培养法和染色体制备方法简单、技术稳定、结果可靠,可用于胎儿染色体疾病的产前诊断。
Objective To evaluate the value of cytogenetic analysis in prenatal diagnosis of early-stage B-guided transabdominal chorion-derived tissue samples. Methods A retrospective analysis of 42 cases of early pregnancy in January 2010 to June 2011 prenatal cytogenetic diagnosis of the case data. Results 42 cases of drawing time 9 to 13 weeks, puncture success rate of 100%, the success rate of 97.6% training, the average incubation time of 10 days found abnormal karyotype in 4 cases. Conclusion It is a safe and feasible method for interventional prenatal diagnosis in early pregnancy by B-guided transabdominal chorionic villi extraction after 9 weeks of pregnancy. Long-term culture of villus cells and chromosome preparation method is simple, stable technology, the results are reliable, can be used for prenatal diagnosis of fetal chromosomal diseases.