1964年Steele等首先确立进行性核上性眼肌麻痹(简称PSO)的临床特征。其表现为进行对称性的核上性眼肌麻痹,颈和上躯体部的肌张力呈僵直状,且有痴呆。少数还有小脑和锥体束的功能障碍。本病多见于男性,常在60岁以后发病,数年内可致 In 1964, Steele et al first established the clinical features of progressive supranuclear ophthalmoplegia (PSO). The performance of the symmetry of the supranuclear ophthalmoplegia, neck and upper body stiffness was stiff, and dementia. A few also have cerebellar and pyramidal tract dysfunction. The disease more common in men, often after 60 years of age, can be caused within a few years