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目的探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)的临床病理、免疫组化特点。方法观察67例胃肠道间质瘤形态学特征及免疫组化染色。结果61.2%胃肠道间质瘤发生在小肠,瘤细胞为梭形或上皮样,或两者混合存在,胞浆嗜酸性较弱,免疫组化表型为CD34+,CD117+。结论胃肠道间质瘤有较独特的免疫组化表型,免疫组化可协助鉴别诊断。
Objective To investigate the clinicopathological and immunohistochemical features of gastrointestinal stromal tumor (GIST). Methods The morphological features and immunohistochemical staining of 67 cases of gastrointestinal stromal tumors were observed. Results 61.2% gastrointestinal stromal tumors occurred in the small intestine. The tumor cells were spindle-shaped or epithelial-like or mixed with each other. The cytosolic eosinophils were weak and the immunohistochemical phenotypes were CD34 + and CD117 +. Conclusion Gastrointestinal stromal tumors have a more unique immunohistochemical phenotype, immunohistochemistry can help differentiate the diagnosis.