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目的探讨和研究注射用头孢噻肟钠在预防胃肠道肿瘤术后感染中的临床效果。方法将2010年4月~2012年3月本院收治的112例胃肠道肿瘤患者作为对象进行研究,按照随机分组的原则将之分为观察组56例及对照组56例,两组患者均行外科肿瘤根治术治疗,对照组术后常规应用头孢噻肟预防感染,观察组则除应用头孢噻肟预防感染之外,在术前3 d至术后1周应用胸腺肽注射液进行辅助预防,对两组患者感染情况、内毒素等相关情况进行统计对比。结果从两组患者的切口感染率来看,观察组患者的总体感染率为8.9%(5/56),对照组患者的总体感染率为26.8%(15/56),观察组显著低于对照组,差异具有统计学意义(P<0.05);两组患者的内毒素水平及IL-6、TNF-α水平较治疗前均明显降低(P<0.05),但观察组患者的IL-2、IL-10水平较治疗前显著升高,较对比组亦具有统计学意义(P<0.05)。结论单纯应用头孢噻肟预防胃肠道肿瘤术后感染的效果一般,考虑原因可能是与患者机体免疫抑制相关,因此建议结合胸腺肽等其他辅助药物进行联合应用,提高预防效果。
Objective To investigate and study the clinical efficacy of cefotaxime sodium for injection in the prevention of postoperative infection of gastrointestinal cancer. Methods A total of 112 patients with gastrointestinal cancer who were treated in our hospital from April 2010 to March 2012 were studied. According to the principle of randomization, they were divided into observation group 56 cases and control group 56 cases. Surgical radical surgery was performed. In the control group, cefotaxime was used routinely to prevent infection. In the observation group, cefotaxime was used to prevent infection, and in the observation group, thymosin injection was used 3 days before surgery to 1 week after surgery to prevent infection. A statistical comparison was made between the two groups of patients for infection, endotoxin and other related conditions. Results From the incision infection rate of the two groups of patients, the overall infection rate in the observation group was 8.9% (5/56), and the overall infection rate in the control group was 26.8% (15/56). The observation group was significantly lower than the control group. In the group, the difference was statistically significant (P<0.05); both endotoxin levels and IL-6 and TNF-α levels were significantly lower than before treatment (P<0.05), but IL-2 was observed in the observation group. The level of IL-10 was significantly higher than before treatment, and it was also statistically significant compared with the control group (P<0.05). Conclusions The use of cefotaxime alone for the prevention of postoperative infection of gastrointestinal tract tumors is generally effective. The reason may be related to the immunosuppression of the patient. Therefore, it is recommended that thymosin and other auxiliary drugs be used in combination to improve the prevention effect.