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用 60 Coγ射线对二级雌性 Wistar大鼠 (体重 ( 2 2 0± 2 0 ) g) 2 2 3只进行 30 Gy全胸单次照射 ,其中照射野为 4 .5cm× 4 .0 cm,照距为 3m,剂量率为 2 .7Gy/ min。分别于照后 3、7、1 4、2 1、2 8、4 2、56、70、90、1 80、2 70、36 5d共 1 2个时间点进行了取材观察。结果表明 ,肺脏病变初期呈急性变化 ,以后转为亚急性或慢性进行性发展过程 ,可大致分为 2个阶段 4个期。早期即急性炎症期或渗出期 ,中期为增生期 ,这 2期合为疾病的第 1阶段 ,称为放射性肺炎。后期即纤维化期 ,晚期即胶原化期 ,这 2期共同构成本病的第 2个阶段 ,称为进行性间质纤维化阶段
The second-order female Wistar rats (body weight (220 ± 20) g) 2 2 3 were irradiated with 60 Co γ ray only by single-dose 30 Gy whole chest irradiation, the irradiation field was 4.5 cm × 4.0 cm The distance is 3m, the dose rate is 2.7Gy / min. The observation was made at 12 time points after 3, 7, 1, 4, 2, 12, 8, 4, 25, 25, 70, 70, 80, 70, The results showed that acute changes in the early stages of lung lesions, subacute or chronic later into the process of progressive development, can be roughly divided into two stages of 4 periods. Early that acute inflammation or exudative period, the middle period for the proliferative phase, the two phases together for the first phase of the disease, known as radiation pneumonitis. Late stage of fibrosis, advanced collagen phase, the two phases together constitute the second phase of the disease, known as progressive interstitial fibrosis stage