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目的：了解14株（亚株）人鼻咽癌细胞的放射生物学特性。材料与方法：采用集落存活分析法分析中国建成的14株（亚株）人鼻咽癌细胞的特性；除了CNE1之外，所有的细胞均为低分化鳞癌细胞，实验求得的放射剂量存活曲线用线性二次模型进行拟合，用Fertil 和Malais 介绍的方法和原理计算存活曲线的初斜率（α），平均抑制剂量（mean inactivation dose, MID）及2 Gy处的存活分数（SF2）。结果：α：0.001～0.81, MID：1.11～2.46, SF2：0.17～0.66, 14株(亚株)鼻咽癌细胞的放射敏感性变化较大,来源同一个母株(SUNE1)的8个亚株之间的放射敏感性存在着差别。结论：鼻咽癌细胞在个体内和个体间变化较大；因此，在临床制定鼻咽癌的治疗计划时，要考虑鼻咽癌的个体放射生物学特性。
Objective: To understand the radiobiological characteristics of 14 (sub-strain) human nasopharyngeal carcinoma cells. MATERIALS AND METHODS: Colony-survival assay was used to analyze the characteristics of 14 (sub-strain) human nasopharyngeal carcinoma cells established in China. All cells except for CNE1 were poorly differentiated squamous cell carcinoma cells. The experimentally obtained radiation dose survival Curves were fitted using a linear quadratic model. The initial slope (α), mean inactivation dose (MID), and survival fraction at 2 Gy (SF2) of survival curves were calculated using the methods and principles described by Fertil and Malais. RESULTS: The radiosensitivity of nasopharyngeal carcinoma cells from 14 strains (sub-strain) varied greatly from α to 0.001 to 0.81, from 1.11 to 2.46 for MID and from 0.17 to 0.66 for SF2. Eight sub-populations of the same parent strain (SUNE1) There is a difference in radiosensitivity between strains. CONCLUSIONS: Nasopharyngeal carcinoma cells vary greatly between individuals and individuals; therefore, the individual’s radiological characteristics of NPC should be considered in the development of a clinical plan for the treatment of NPC.