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目的探讨血清5’核苷酸酶(5’-NT)、α-L-岩藻糖苷酶(AFU)、碱性磷酸酶(ALP)和γ-谷氨酰转移酶(GGT)检测在肝胆疾病诊断中的临床价值。方法回顾性分析2014年6月—2015年6月泰和县人民医院收治的102例肝胆疾病患者的临床资料,根据疾病类型分为肝胆管结石组19例,慢性肝炎组18例,胆汁淤积肝炎组17例,肝炎后肝硬化组17例,胆囊结石组16例,原发性肝癌组15例。选取20例健康体检者为对照组。比较不同肝胆疾病患者与对照组血清样本中5’-NT、AFU、ALP和GGT水平及阳性率。结果肝胆管结石组、胆汁淤积肝炎组、肝炎后肝硬化组、胆囊结石组、原发性肝癌组患者血清5’-NT、AFU、ALP和GGT水平均高于对照组,慢性肝炎组AFU水平高于对照组,差异有统计学意义(P<0.05)。四项联合检测阳性率高于血清酶单项检测阳性率,差异有统计学意义(P<0.05)。结论血清5’-NT、AFU、ALP和GGT可作为肝胆疾病诊断的重要指标,联合检测有利于肝胆疾病的诊断和鉴别。
Objective To investigate the detection of serum 5’-NT, α-L-fucosidase (AFU), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) The clinical value of diagnosis. Methods The clinical data of 102 cases of hepatobiliary diseases admitted to Taihe People’s Hospital from June 2014 to June 2015 were retrospectively analyzed. According to the types of diseases, there were 19 cases of hepatolithiasis, 18 cases of chronic hepatitis and 1 case of cholestatic hepatitis 17 cases, hepatitis cirrhosis group 17 cases, gallstone group 16 cases, primary liver cancer group 15 cases. Twenty healthy subjects were selected as the control group. The levels and positive rates of 5’-NT, AFU, ALP and GGT in serum samples from patients with hepatobiliary diseases and controls were compared. Results The serum 5’-NT, AFU, ALP and GGT levels in patients with hepatolithiasis, cholestatic hepatitis, posthepatitic cirrhosis, gallstone and primary liver cancer were significantly higher than those in control group. The levels of AFU in chronic hepatitis group Higher than the control group, the difference was statistically significant (P <0.05). The positive rate of four combined tests was higher than that of single test of serum enzymes, the difference was statistically significant (P <0.05). Conclusion Serum 5’-NT, AFU, ALP and GGT can be used as important indicators in the diagnosis of hepatobiliary diseases. Combined detection is beneficial to the diagnosis and identification of hepatobiliary diseases.