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超分子组装体由于具有适合的微纳米尺寸、可控的结构和良好的生物相容性等特点,极大地促进了药物/基因传递体系的发展。拓扑结构(如形貌、尺寸)是影响药物/基因传递体系的重要因素,这方面研究正成为这一领域的研究热点。本文综述了调控组装体形貌的主要手段,包括聚合物链结构与组成、组装条件、外界刺激及聚合诱导的组装体形貌,初步探讨了微观形貌对药物/基因传递体系的影响,并对这一领域进行了展望。
Supramolecular assemblies have greatly facilitated the development of drug / gene delivery systems due to their suitable micro-nano size, controlled structure, and good biocompatibility. Topological structure (such as morphology, size) is an important factor affecting the drug / gene delivery system, and research in this area is becoming a research hotspot in this field. This review summarizes the main means of controlling the morphology of the assembly, including the structure and composition of polymer chains, assembly conditions, external stimuli and the morphology of assembly induced by polymerization. The effects of morphology on the drug / gene delivery system are also discussed Looking forward to this area.