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1989年8月至1993年9月收治74例宫颈鳞癌进行放疗,为研究药物盐水预防、治疗放射性直肠炎的可行性,将74例配对分为药物盐水灌肠组(A组)38例,对照组(B组)36例。两组放疗情况相同,以~(60)Co外照射及~(60)Co腔内后装,全盆腔外照射DT35Gy/4W,宫旁4野DT20～25Gy/3W,腔内A点剂量DT30～35Gy/6～7次,放疗中A组用药物盐水保留灌肠,每日早晚各一次,放疗结束后3个月内每晚一次,药物盐水成分:生理盐水30毫升,庆大霉素4万单位,地塞米松5毫克,维生素C 0.5克,锡类散2毫升;B组单放疗不作上述灌肠治疗,观察早晚期放射性直肠炎的发生率。放疗DT40Gy时,A组为0,B组25%,放疗结束时A组21％,B组50％,P<0.01,放疗结束后一年A组为3％,B组17a％,P<0.05,且A组出现症状轻药物盐水灌肠可使早期直肠反应推迟,可降低早晚期直肠反应的发生率,能减轻痛苦,提高患者的生存质量。
From August 1989 to September 1993, 74 patients with cervical squamous cell carcinoma were treated with radiotherapy. To study the feasibility of drug saline prevention and treatment of radiation proctitis, 74 patients were divided into three groups: drug saline enema group (A group) Group (B group) 36 cases. The patients in the two groups had the same radiotherapy condition. The patients were treated with ~ (60) Co external irradiation and ~ (60) Co intracameral afterloading, total pelvic extracorporeal DT35Gy / 4W, 35Gy / 6 ~ 7 times, radiotherapy group A with saline retention enema, once a day sooner or later, within 3 months after the end of radiotherapy once a night, the composition of saline medicine: saline 30 ml, gentamicin 40,000 units , Dexamethasone 5 mg, vitamin C 0.5 g, tin powder 2 ml; B group radiotherapy without these enema treatment, early and late observation of the incidence of proctitis. Radiotherapy DT40Gy, A group of 0, B 25%, 21% of the end of radiotherapy in group A, B 50%, P <0.01, one year after radiotherapy group A was 3%, B group 17a%, P <0.05 , And group A symptoms of light medicine saline enema delayed early rectal response can reduce the incidence of early and late rectal reactions can reduce pain and improve patient quality of life.