本文报道了4价(A、C、Y、W135)脑膜炎球菌多糖菌苗对儿童的免疫原性和安全性.受试者为26名(男性16名,女性10名)3～13岁(平均7.46岁)的健康儿童.他们以前均未接种过脑膜炎球菌菌苗.每人皮下注射含有4价多糖各50μg的菌苗0.5ml,在接种当天和第28天后对21名儿童各采血6ml作血清学检测,用食品和药物管理局生物制品处规定的方法测定杀菌抗体,观察局部和全身反应5天. This article reports the immunogenicity and safety of 4-valent (A, C, Y, W135) meningococcal polysaccharide vaccine in children, with 26 subjects (16 males and 10 females) aged 3 to 13 years Average 7.46 years old) who had never been vaccinated with meningococcal vaccine, 0.5 ml of vaccine containing 50 μg each of the 4-valent polysaccharide was subcutaneously injected into each patient, and 6 ml each of 21 children was collected on the day of inoculation and day 28 Serological tests were performed to determine bactericidal antibodies using the method prescribed by the Food and Drug Administration’s Biological Products and local and systemic reactions were observed for 5 days.