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对临床诊断的５３例间质性肺病患者进行肺弥散量（ＤＬＣＯ）、ＣＯ转送系数（ＫＣＯ）测定和动脉血气分析。结果：ＤＬＣＯ减低３７例（６９．８％），ＫＣＯ减低３３例（６２．３％），ＰａＯ２降低４３例（８１．１％），ＡａＤＯ２增高４０例（７５．５％），ＡａＤＯ２增高与ＤＬＣＯ、ＫＣＯ减低明显相关，相关系数分别为ｒ＝－０．５３９４，－０．８０９３。提示：间质性肺病时换气功能障碍系由通气／血流比例失调和弥散受阻引起，综合多项换气功能指标能较客观地推断病理损伤程度，提高诊断的准确性
53 patients with clinically diagnosed pulmonary interstitial lung disease volume (DLCO), CO transfer coefficient (KCO) determination and arterial blood gas analysis. Results: DLCO decreased in 37 cases (69.8%), KCO decreased in 33 cases (62.3%), PaO2 decreased in 43 cases (81.1%), AaDO2 increased in 40 cases (75.5% , KCO decreased significantly correlated, the correlation coefficients were r = -0.5394, -0.8093. Tip: interstitial lung disease ventilatory dysfunction caused by the ventilation / blood flow imbalance and diffuse obstruction caused by a combination of a number of indicators of ventilation can objectively infer the degree of pathological damage and improve the diagnostic accuracy