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目的探讨左氧氟沙星联合化疗对复治涂阳肺结核患者机体免疫功能的影响。方法以2014年2月至2016年8月96例复治涂阳肺结核患者作为研究对象,随机分为两组,每组48例。对照组予以化疗治疗,观察组予以左氧氟沙星联合化疗治疗。治疗后,对比两组免疫功能、治疗总有效率。结果治疗后,观察组CD3~+、CD4~+、CD8~+水平及治疗总有效率高于对照组,CD4~+/CD8~+低于对照组,差异有统计学意义(P<0.05)。结论对复治涂阳肺结核患者予以左氧氟沙星联合化疗治疗的效果显著,可通过改善患者的外周血T细胞亚群水平发挥调节免疫功能作用。
Objective To investigate the effect of levofloxacin combined with chemotherapy on the immune function of patients with retreatment smear positive pulmonary tuberculosis. Methods From February 2014 to August 2016, 96 patients with retreatment of smear positive pulmonary tuberculosis were randomly divided into two groups (n = 48 in each group). The control group was treated with chemotherapy, the observation group was levofloxacin combined with chemotherapy. After treatment, compared with the two groups of immune function, the total effective rate of treatment. Results After treatment, the levels of CD3 ~ +, CD4 ~ + and CD8 ~ + in the observation group were significantly higher than those in the control group (P <0.05) . Conclusions The levofloxacin combined with chemotherapy is effective in treating patients with relapsed and smear-positive pulmonary tuberculosis and can play an immunologic function by improving the level of T lymphocyte subsets in peripheral blood.