目的探讨龙黄合剂体外抑Ｈｐ作用，及对Ｈｐ阳性十二指肠溃疡的疗效．方法采用纸片扩散法和琼脂稀释法，对龙黄合剂中单味中药及复合制剂进行体外抑Ｈｐ实验，并与部分中成药抑Ｈｐ效果对比．将１２８例Ｈｐ阳性十二指肠溃疡随机分成龙黄合剂组（Ａ组），雷尼替丁＋呋喃唑酮组（Ｂ组）及龙黄合剂＋呋喃唑酮＋雷尼替丁（Ｃ组）３组进行治疗，观察各组溃疡愈合率，复发率，Ｈｐ根除率，胃窦粘膜病理好转率，药物副反应发生率．结果龙黄合剂有较好体外抑Ｈｐ作用．Ｃ组Ｈｐ根除率为８４８％，溃疡１ａ复发率１３５％，胃窦粘膜炎症病理好转率为６５３％，副反应发生率为１３０％，均优于Ａ组（４５２％，３７５％，５７１％，７１％）及Ｂ组（３７５％，５００％，３７５％，１９５％），统计学处理有显著或极显著差异（Ｐ＜００５或００１）．３组溃疡愈合有效率分别为Ｃ组１０００％，Ａ组９００％，Ｂ组９０５％，统计学处理无显著差异（Ｐ＞００５）．结论体外试验证明龙黄合剂对Ｈｐ有较好抑制作用，龙黄合剂＋雷尼替丁＋呋喃唑酮用于Ｈｐ阳性的十二指肠溃疡治疗，可提高Ｈｐ根除率，减少复发率，副作用小，价格低廉，服用方便，适合国情，值得推广 Objective To investigate the inhibitory effect of Longhuang Mixture on Hp in vitro and its effect on Hp-positive duodenal ulcer. Methods The disk diffusion method and agar dilution method were used to detect Hp in vitro of single Chinese herbal medicine and compound preparation of Longhuang mixture in vitro and compared with that of some proprietary Chinese medicines. 128 cases of Hp positive duodenal ulcer were randomly divided into three groups: Longhuang Mixture Group (A), Ranitidine + Furazolidone (B) and Longhuang Mixture + Furazolidone + Ranitidine (C) The healing rate, relapse rate, Hp eradication rate, pathological improvement rate of antral mucosa and the incidence of adverse drug reactions were observed. Result Longhuang mixture has a better role in inhibiting Hp in vitro. In group C, the eradication rate of Hp was 848%, the recurrence rate of ulcer 1a was 135%, the pathological improvement rate of gastric antral mucosa was 653%, and the incidence of side effects was 130% (375%, 500%, 375%, 195%) were statistically significant or statistically significant Very significant difference (P <0  05 or 0  01). The effective rates of healing of ulcer in group 3 were 100.0% in group C, 90.0% in group A and 90.5% in group B, respectively, with no statistical difference (P> 0.05). Conclusion Long Huang Mixture can inhibit the growth of Hp in vitro. Long Long Mixture + Ranitidine + Furazolidone can be used to treat Hp-positive duodenal ulcer, which can improve the Hp eradication rate, reduce the recurrence rate, reduce the side effects, Low prices, easy to take, suitable for the national conditions, it is worth promoting