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目的探讨胃微血管系统（ＧＭＳ）的扩张瘀血与门脉高压性胃病变及粘膜出血（ＰＨＧＭＨ）的关系．方法观察ＰＨＧＭＨ模型鼠（ｎ＝３４）的出血率、严重性分级及出血部位分布．形态测量法观察胃粘膜微血管直径（ＤＧＭＭ）、粘膜下小静脉管径比（ＰＳｍＶＤ）和粘膜下厚度（ＳｍＴ）改变，并分期观察与胃病变及粘膜出血的关系．结果①ＰＨＧＭＨ鼠的ＤＧＭＭ（４０１μｍ±３０μｍ），ＰＳｍＶＤ（０５０±００３），ＳｍＴ（１３９４μｍ±５９μｍ）以及出血率（９１２％）和严重性分级（ｇｒａｄｅ，２２７±０２０）均与对照有显著或非常显著差异（Ｐ＜００５及Ｐ＜００１）．②随门脉高压病程进展，上述各参数均呈增加趋势，尤其ＰＨＧＭＨⅡ鼠的ＰＳｍＶＤ（０５６±００４）、ＳｍＴ（１５５４μｍ±６６μｍ）及严重性分级（ｇｒａｄｅ，２６０±０２５）均与ＰＨＧＭＨⅠ鼠有显著差异（Ｐ＜００５）．同时出血率及严重性分级与ＳｍＴ和ＰＶＰ水平同步增加，而与ＤＧＭＭ和ＰＳｍＶＤ的增加不同步．③ＰＨＧＭＨ鼠出血部位分布以腺胃体部多见，并与对照有相似分布（２×ｋχ２＝３５０，Ｐ＞００５）．④出血部位粘膜表层上皮脱落缺?
Objective To investigate the relationship between the expansion of gastric capillary system (GMS) and portal hypertensive gastropathy and mucosal hemorrhage (PHGMH). Methods The bleeding rate, severity grade and distribution of bleeding sites in PHGMH model rats (n = 34) were observed. Gastric mucosal microvessel diameter (DGMM), submucosal venous diameter ratio (PSmVD) and submucosal thickness (SmT) were observed by morphological measurement. The relationship between gastric mucosal bleeding and gastric mucosal hemorrhage was observed by staging. Results ①The DGMM (401 ± 30μm), PSmVD (050 ± 003), SmT (1394μm ± 59μm) and the bleeding rate (912%) in PHGMH mice and the severity Grade (227 ± 020) was significantly or very significantly different from the control (P <005 and P <001). ② With the progression of portal hypertension, the above parameters showed an increasing trend, especially PSMVD (056 ± 004), SmT (1554μm ± 66μm) and severity grading grade, 260 ± 025) were significantly different from PHGMHⅠ mice (P <005). At the same time, the hemorrhage rate and severity grading increased synchronously with the levels of SmT and PVP, but not with the increase of DGMM and PSmVD. ③ PHG MH mouse hemorrhage parts of the distribution of gastric body more common, and with a similar distribution (2 × kχ2 = 3 50, P> 0 05). ④ Bleeding site mucosal epithelial shedding missing?