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鼻咽癌的标准治疗方法是放射治疗,但超过60%的患者确诊时已属局部晚期或晚期,单纯放疗后的局部复发率及远处转移率较高。鼻咽癌也是化疗敏感性肿瘤,放疗联合应用化疗可显著改善局部晚期鼻咽癌的疗效,近年来的研究也表明以同步放化疗的治疗方式有益于提高总生存率及无瘤生存率,而放疗前新辅助化疗及放疗后辅助化疗作用尚不明确。本文综述了近年来局部晚期鼻咽癌放疗加化疗综合治疗的现状及研究进展。
The standard treatment of nasopharyngeal carcinoma is radiation therapy, but more than 60% of patients are already diagnosed locally advanced or advanced, the local recurrence rate after radiotherapy and distant metastasis rate higher. Nasopharyngeal carcinoma is also a chemotherapy-sensitive tumor. Radiotherapy combined with chemotherapy can significantly improve the efficacy of locally advanced nasopharyngeal carcinoma. In recent years, studies have shown that concurrent chemoradiation treatment is beneficial to improve the overall survival and tumor-free survival rate, Neoadjuvant chemotherapy before radiotherapy and adjuvant chemotherapy after radiotherapy is not yet clear. This review summarizes the recent advances in the treatment of locally advanced nasopharyngeal carcinoma combined with radiotherapy and chemotherapy.