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业已证明,在类风湿性关节炎、红斑性狼疮以及肾小球性肾炎等急性变态反应性炎症疾病中,补体激活起着重要作用。因此,补体介导过程中的化学控制,给急性炎症有关疾病的治疗带来了希望。通常认为,可以通过阻断由于炎症过程而引起的细胞刺激物的产生或作用,来控制补体的消耗,以治疗某些疾病。这类刺激物包括多核白细胞的化学趋化物质,非细胞毒的酶分泌诱导剂,组胺释放物质以及通透性因子。这些综合性反应在很大程度上是通过C5a和C3a,以及C3和C5裂解产物的药理作用而实现的。因
It has been demonstrated that complement activation plays an important role in acute allergic inflammatory diseases such as rheumatoid arthritis, lupus erythematosus and glomerulonephritis. Therefore, chemical control of complement-mediated processes offers hope for the treatment of acute inflammation-related diseases. It is generally believed that the depletion of complement can be controlled by blocking the production or effect of cellular stimuli as a result of the inflammatory process to treat certain diseases. Such stimuli include chemotactic substances of multicellular leukocytes, non-cytotoxic enzyme secretion inducing agents, histamine releasing substances, and permeability factors. These synthetic reactions are largely mediated by the pharmacological effects of C5a and C3a, as well as the cleavage products of C3 and C5. because