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探讨舒必利预防/控制非顺铂化疗所致迟发性恶心呕吐的效果。方法 :采用自身对照法 ,观察104例恶性肿瘤患者 ,对以非顺铂化疗患者于第1周期口服舒必利 ,第2周期肌肉注射胃复安 ,预防消化道迟发性恶心、呕吐 ,疗效对比观察。结果 :第2、3天有效率舒必利为95 2 %、94 2 % ,胃复安为73 1 %、74 % ,二者之间有显著统计学差异 (P<0 05)。椎体外系反应 ,舒必利1 9 % ,胃复安7 7 %。结论 :舒必利止吐效果优于胃复安,副作用轻
To investigate the effect of sulpiride in preventing / controlling delayed nausea and vomiting caused by non-cisplatin chemotherapy. Methods: A total of 104 patients with malignant tumor were treated with non-cisplatin chemotherapy by self-control method. The patients were given sulpiride in the first cycle and metoclopramide in the second cycle to prevent the delayed nausea and vomiting. . Results: On the 2nd and 3rd days, the effective rate of sulpiride was 95 2%, 94 2%, and metoclopramide 73 1% and 74% respectively. There was a significant difference between the two (P <0.05). Vertebral body reaction, sulpiride 19%, metoclopramide 77%. Conclusion: The effect of sulpiride is better than metoclopramide with less side effects