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作栓剂基质用的柯柯豆脂,由于产量較少,价格高昂,远不能滿足医药上的需要,因此寻求其代用品已成为当前药剂学上一个研究課題。自茴香油中分离出固体脂肪,经试验认为可作栓剂基质。S.Rangaswami等自檳榔中得到一种固体脂肪,熔点36°～38℃,经配伍及粘膜等試驗,认为可代柯柯豆脂作栓剂基质用。蔣伯誠自大戟科植物烏桕中分离出固体脂肪,但熔点較高(38°～42℃),须用低熔点油脂調节后方能使用。M.L.Schroff等自芒果种子中,桂承会自猴香子中,J.S.Robertson自四种婆罗双树属植物
Ke Ke bean fat used as a suppository base, because of the small amount of production, high prices, far from meeting the needs of medicine, seeking for its substitute has become a current research topic in pharmacy. Separation of solid fat from fennel oil has been experimentally considered to be a suppository base. S.Rangaswami et al. obtained a solid fat from betel nut, with a melting point of 36°-38°C. After compatibility and mucous membrane tests, it was considered that kecobean oil can be used as a suppository base. Jiang Bocheng segregated solid fat from the black plant of Polygonaceae, but its melting point was relatively high (38° to 42°C) and it was necessary to use low-melting-point grease before it could be used. M.L. Schroff et al. from mango seeds, Gui Chenghui from Monkey and J.S. Robertson from four sal plants