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目的 :探讨恶性肿瘤手术前后患者血液纤溶系统的变化。方法 :测定胃癌 2 3例、乳腺癌 1 6例术前和术后 1 d、1 0 d以及对照组 51例血液纤溶系统 5项指标 ,并进行对比研究。结果 :胃癌与乳腺癌纤溶活性明显升高 ,术前 Plg:A明显降低 ,术后 1 d上述异常进一步加重 ,而术前 t- PA低于正常对照 ,术后逐渐升至正常。术前 PAI高于正常对照 ,术后逐渐降至正常。癌肿切除后 ,纤溶系统 5项指标逐渐恢复至正常水平。结论 :恶性肿瘤患者术前即存在纤溶活性增强 ,应引起临床高度重视 ,以预防血栓及出血性疾病的发生。
Objective: To investigate the changes of blood fibrinolytic system in patients with malignant tumors before and after surgery. Methods : To measure 23 cases of gastric cancer, 16 cases of breast cancer before surgery, 1 day and 10 days after operation, and 51 indicators of blood fibrinolytic system in 51 cases in the control group. Results : The fibrinolytic activity of gastric cancer and breast cancer increased significantly. Preoperative Plg:A was significantly decreased. The above abnormalities were further aggravated one day after surgery. The preoperative t-PA was lower than the normal control and gradually increased to normal after surgery. Preoperative PAI was higher than normal controls and gradually decreased to normal after surgery. After removal of the cancer, the 5 indicators of the fibrinolytic system gradually returned to normal levels. Conclusion: Patients with malignant tumors have enhanced fibrinolytic activity before surgery. Clinical attention should be given to prevent the occurrence of thrombotic and hemorrhagic diseases.