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目的探讨胃癌患者外周血T淋巴细胞嗜银蛋白含量在手术前后的变化以及免疫调节剂参芪扶正注射液(简称参芪液)对其的影响。方法根据85例患者是否行根治术分为两组,每组再根据是否静脉滴注参芪液随机分两组,分别对其手术前后和12名健康人进行外周血T淋巴细胞嗜银蛋白含量的检测。结果胃癌患者T淋巴细胞嗜银蛋白含量较健康人显著降低(P<0.01);根治组(64例)术后T淋巴细胞嗜银蛋白含量较术前明显升高(P<0.05或P<0.01),应用参芪液治疗的患者(36例)升高更加显著(P<0.05);非根治组(21例)手术前后无明显变化,但应用参芪液治疗的患者(13例)升高显著(P<0.05)。结论胃癌患者T淋巴细胞免疫功能低下,在其手术后辅助性应用参芪液可明显改善其细胞免疫功能。
Objective To investigate the changes of peripheral blood T-lymphocyte argyrophilic protein in patients with gastric cancer before and after operation and the effect of Shenqi Fuzheng injection (abbreviated as Shenqi liquid) on it. Methods According to 85 patients undergoing radical surgery were divided into two groups, each group according to whether the intravenous infusion of Shenqi solution were randomly divided into two groups, respectively, before and after surgery and 12 healthy people were peripheral blood T lymphocyte argyrophil protein content The test. Results The content of argyrophilic protein of T lymphocytes in patients with gastric cancer was significantly lower than that in healthy people (P <0.01). The content of argyrophilic protein in T lymphocytes of patients in radical group was significantly higher than that before operation (P <0.05 or P <0.01) ) (P <0.05). There was no significant change in the non-radical treatment group (21 cases) before and after operation, but the patients treated with Shenqi solution (13 cases) Significant (P <0.05). Conclusion The immune function of T lymphocytes in patients with gastric cancer is poor. After its operation, Shenqi liquid, which is adjuvant, can obviously improve its cellular immune function.