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本文合成了一系列的反丁烯二酸芳香醇(苄醇、苯乙醇、苯丙醇、邻溴苄醇)酯,所得产物的NMR、FTIR表征结果与理论预测一致。用光电比浊法研究其抑菌活性,反丁烯二酸芳香醇酯表现出较强的抑菌活性,随着芳香醇的链长的增加对四种细菌的抑制作用也增强,芳香醇卤代后,与反丁烯二酸所生成的二酯的抑菌作用也得到加强。反丁烯二酸芳香醇酯有望成为高效抑菌剂。
In this paper, a series of aromatic fumaric acid (benzyl alcohol, phenylethyl alcohol, phenylpropanol, o-bromobenzyl alcohol) esters were synthesized. The results of NMR and FTIR analysis of the obtained products are consistent with the theoretical predictions. The antitumor activity was studied by photoelectric turbidimetry. Aromatic alcohol fumarate showed strong antibacterial activity. With the increase of chain length of aromatic alcohol, the inhibitory effect on four kinds of bacteria was also enhanced. After the generation, and fumaric acid generated by the formation of the diester bacteriostatic effect has also been strengthened. Aromatic alcohol fumarate is expected to become a highly effective bacteriostat.