先天性神经母细胞瘤和胰岛细胞增生症同时发生在严重低血糖的新生儿,可能代表一种少见的复合性神经嵴疾病。尽管在儿科肿瘤中神经母细胞瘤比较常见,但伴有严重低血糖者确很少见。已知的报导仅四例。本文报告的一例为足月男婴,重2400克,有呼吸困难、全身浮肿及紫斑,肝肿大。无多发性内分泌腺瘤综合症及儿童肿瘤之家族史。化验发现高胆红素血症和血小板减少。血浆胰岛素(空腹)16—51·5μu/ml(正常2—25 Congenital neuroblastoma and pancreatic islet cell hyperplasia occur in newborns with severe hypoglycemia, and may represent a rare form of complex neurological disease. Although neuroblastoma is more common in pediatric tumors, it is rarely seen with severe hypoglycemia. There are only four known reports. One case reported in this article is a full-term baby boy weighing 2,400 grams, with dyspnea, systemic edema and purpura, and hepatomegaly. No multiple endocrine neoplasia syndrome and family history of childhood cancer. Laboratory tests found hyperbilirubinemia and thrombocytopenia. Plasma insulin (fasting) 16-51·5μu/ml (Normal 2-25