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根据长期的临床经验,发现某些药物如水杨酸钠制剂可导致胃、十二指肠粘膜损伤或出血。吸烟或饮酒者易伴发胃肠损伤或溃疡。本文复习近年的文献,探讨药物、酒精和吸烟对胃肠粘膜的损伤和损伤机制。药物一些抗炎药物如乙酰水杨酸(acetylsalicylic acid,ASA)和非甾体抗炎化合物(nonsteroidal anti-inflammatory drug,NSAID)或激素可以导致人和实验动物的急性胃、十二指肠粘膜损伤。很多报道是可信服的,其损伤的作用机制仍不完全清楚。可能是增加了粘膜微出血和细胞脱落率,从而降低了粘膜电位
Based on long-term clinical experience, it has been found that certain drugs such as sodium salicylate formulations can cause gastric and duodenal mucosal damage or bleeding. Smoking or drinking alcohol easily accompanied by gastrointestinal injury or ulcer. This review of recent literature to explore the drug, alcohol and smoking on the gastrointestinal mucosal injury and injury mechanisms. Drugs Some anti-inflammatory drugs such as acetylsalicylic acid (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) or hormones can cause acute gastric and duodenal mucosal injury in humans and laboratory animals . Many reports are credible, the mechanism of its injury is still not fully understood. May be increased mucosal hemorrhage and cell shedding rate, thereby reducing the mucosal potential