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目的研究高血压脑出血患者外周血中白细胞介素2(IL-2)、可溶性白细胞介素2受体(sIL-2R)表达的变化规律,探讨其间相互关系及临床意义。方法采用酶联免疫吸附法(ELISA)测定患者IL-2、sIL-2R的含量。结果高血压脑出血组IL-2含量(pg/ml)为67.76±32.62,与健康对照组(127.15±57.05)相比明显降低(P<0.01),sIL-2R含量(pg/ml)为96.91±50.14,与健康对照组(92.11±34.1)相比则明显升高(P<0.05)。结论高血压脑出血患者出现免疫功能低下,临床检测患者IL-2、sIL-2R含量在高血压脑出血的发生、发展、治疗、转归及预后方面具有重要的临床指导意义。
Objective To investigate the expression of interleukin 2 (IL-2) and soluble interleukin 2 receptor (sIL-2R) in peripheral blood of patients with hypertensive intracerebral hemorrhage (ICH) and to explore the relationship and clinical significance. Methods The levels of IL-2 and sIL-2R in patients were determined by enzyme-linked immunosorbent assay (ELISA). Results Compared with healthy control group (127.15 ± 57.05), IL-2 level (pg / ml) in hypertensive intracerebral hemorrhage group was significantly lower (p <0.01) and sIL-2R level (pg / ml) was 67.76 ± 32.62 ± 50.14, which was significantly higher than that of the healthy control group (92.11 ± 34.1) (P <0.05). Conclusion The patients with hypertensive intracerebral hemorrhage have immunocompromised patients. The levels of IL-2 and sIL-2R in patients with hypertensive intracerebral hemorrhage have important clinical significance in the occurrence, development, treatment, prognosis and prognosis of hypertensive intracerebral hemorrhage.