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心房颤动已经成为临床发病率最高的心血管疾病之一.使用冷冻消融完成环肺静脉隔离治疗心房颤动是一项安全且有效的手段;但是目前心房颤动射频导管消融术后复发率仍较高,早期有效地预测心房颤动复发能为临床工作者筛选适应证更佳的患者,并为患者制定更好的个体化治疗策略,提高冷冻消融术治疗心房颤动的成功率.最新研究显示心肌损伤标志物、心肌抗体、4q25单核苷酸多态性、血清尿酸水平可能是心房颤动冷冻消融术后复发的独立预测因子.“,”Atrial fibrillation(AF)has become one of the largest cardiovascular epidemics in clinical practice.The use of cryoballoon ablation(CA)has been a safe and effective method for pulmonary vein isolation in the treatment of paroxysmal atrial fibrillation .However,the recurrence of AF is still high even with the use of CA.Predicting the recurrence of AF early and effectively can help doctors choose suitable patients,develop individualized ablation treatment strategies and eventually improve the successful rate of radiofrequency catheter ablation . Recent studies indicate that myocardial injury markers ,cardiac autoantibody ,chromosome 4q25 single-nucleotide polymorphisms and serum uric acid level are each independent predictors of the recurrence of AF after CA .