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阿洛司琼是一种高选择性 5- HT3受体拮抗剂 ,现正试用于治疗过敏性肠综合征 (IBS)。药效学特征 阿洛司琼 (0 .0 1～ 1 .0μmol·L-1)阻滞游离豚鼠肠肌层和粘膜下层由 5- HT3介导的神经元快速去极化 ;该效应呈剂量依赖性 (IC50约为 55nmol· L-1)。高浓度阿洛司琼 (1μmol·L-1
Alosetron, a highly selective 5-HT3 receptor antagonist, is currently being tested for the treatment of irritable bowel syndrome (IBS). Pharmacodynamics Alosetron (0.01-1.0 μmol·L-1) blocked the rapid depolarization of 5- HT3-mediated neurons in the intestinal myometrium and submucosa of free guinea pigs. The effect was dose-dependent Dependence (IC50 is about 55nmol · L-1). High concentration of alosetron (1μmol·L-1