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目的：报道２例非糖尿病非绿脓杆菌所致恶性外耳道炎病例。方法：回顾性分析２例恶性外耳道炎的病史资料、临床表现、实验室检查结果、治疗经过，并复习文献。结果：２例恶性外耳道炎患者均为男性，均无糖尿病史，实验室检查亦无糖尿病的证据，均表现为外耳道的进行性坏死性炎症；例１分离出金黄色葡萄球菌，治疗后已１年无复发，仍在随访中；例２为奇异变形杆菌，３次复发住院治疗后失访。结论：恶性外耳道炎可发生于非糖尿病患者，亦可由绿脓杆菌以外的其他细菌所引起，早期诊断困难，根据药敏试验结果合理使用抗生素和局部清洁是治疗的主要方法。适当掌握停药时机是预防复发的关键
Objective: To report two cases of malignant otitis media caused by non-diabetic non-Pseudomonas aeruginosa. Methods: Two cases of malignant otitis externa were analyzed retrospectively. The clinical data, clinical manifestations, laboratory findings and treatment were retrospectively reviewed. Results: Two patients with malignant otitis externa were all male, no history of diabetes and laboratory tests without evidence of diabetes. All of them showed progressive necrotizing inflammation of the external auditory canal. Example 1 Staphylococcus aureus was isolated and treated 1 No recurrence of the year, are still under follow-up; Case 2 is Proteus mirabilis, three were hospitalized after recurrent loss of follow-up. Conclusions: Malignant otitis externa can occur in non-diabetic patients as well as other bacteria other than Pseudomonas aeruginosa. Early diagnosis is difficult. Reasonable use of antibiotics and local cleaning are the main methods of treatment based on drug susceptibility test results. Appropriate to grasp the timing of withdrawal is the key to preventing recurrence