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室温下,用醋酸硝酰(浓硝酸与冰醋酸混合物)将10-羟基-5,10-二氢磷杂吖嗪-10-氧化物硝化5 h,得10-羟基-2-硝基-5,10-二氢磷杂吖嗪-10-氧化物(74%)。后者在中性介质中,用5%Pd/C作催化剂,氢化还原得到2-氨基-10-羟基-5,10-二氢磷杂吖嗪-10-氧化物(70%)。经过Salmonella/m amm alian m icrosom e assay测试,该氨基物表现为非诱变性,用它作为重氮组分,分别与3种吡唑啉酮系衍生物偶合得到3种红色酸性偶氮染料。研究了这些染料的光谱性质及其应用性能。结果表明,所合成的新染料比由一般芳香胺与吡唑啉酮形成的偶氮化合物具有深色效应。用波谱分析确定了中间体及其染料的结构。
Nitration of 10-hydroxy-5,10-dihydroprophosphazine-10-oxide with nitroxyl acetate (a mixture of concentrated nitric acid and glacial acetic acid) for 5 h at room temperature gave 10-hydroxy-2- , 10-dihydroprophosphazine-10-oxide (74%). The latter was hydrogenated in neutral medium using 5% Pd / C as a catalyst to give 2-amino-10-hydroxy-5,10-dihydroprophosphazine-10-oxide (70%). After Salmonella / m amm alian m icrosom e assay, the amino group showed non-mutagenicity, it was used as a diazo component, respectively, and three pyrazolone derivatives were coupled to obtain three kinds of red acid azo dyes . The spectral properties of these dyes and their application properties were studied. The results show that the new dye synthesized has a darker effect than the azo compounds formed by typical aromatic amines and pyrazolones. The structure of intermediates and their dyes was confirmed by spectral analysis.