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目的 :研究当归对红细胞变形性和聚集性影响。方法 :健康献血者红细胞 ,自身血浆稀释至红细胞压积为 40 %。用红细胞聚集仪和激光衍射光学旋转细胞分析仪分别测定红细胞聚集性和变形性。结果 :当归组加入当归注射液 2 0mg/ml孵育后与正常对照组比较 ,可显著降低红细胞聚集速度 (Ta :2 .5 9± 0 .35 ,Tf:33.5 4± 2 .6 3vsTa :1.80±0 .16 ,Tf:2 7.11± 1.78,P <0 .0 5 ) ,但不影响红细胞解聚能力。加入Ca2 + 螯合剂可使红细胞变形性降低。当归可以显著逆转A2 3187导致的红细胞变形性降低 (EI:0 .2 9±0 .0 47vs 0 .17± 0 .0 2 4,P <0 .0 1)。结论 :当归可以降低正常红细胞聚集速度 ,减轻Ca2 + 螯合剂导致的红细胞变形性降低。
Objective: To study the effect of Angelica on the deformability and aggregation of red blood cells. Methods : Healthy blood donor red blood cells were diluted to hematocrit 40%. Erythrocyte aggregation and deformability were measured using a red cell aggregometer and a laser diffraction optical rotating cell analyzer, respectively. RESULTS: Compared with the control group, the angelica group could significantly reduce the rate of erythrocyte aggregation (Ta : 2.59 ± 0.35, Tf: 33.5 4 ± 2 .6 3vsTa : 1.80 ± ) after incubating with Angelica sinensis injection at 20 mg/ml. 0.16, Tf:2 7.11± 1.78, P <0.05, but does not affect the ability of red blood cells to depolymerize. The addition of Ca2 + chelator reduces red blood cell deformability. Angelica could significantly reverse the reduction of red blood cell deformability induced by A2 3187 (EI: 0.29±0. 0 47vs 0 .17± 0 . 0 2 4, P <0.01). Conclusion: Angelica can reduce the rate of normal red blood cell aggregation and reduce the red blood cell deformability caused by Ca2 + chelator.