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五 ＩＬ-1对脑功能的影响及其作用机制1、致热效应:ＩＬ-1的最早名称─内源性致热原最能反映它的致热效应。给家兔注射30～50ｎｇ/ｋｇ纯化的这种蛋白质能引起发热,后来发现脑内给予ＩＬ-1引起最大效应的剂量比外周给药引起相同效应的剂量要小得多,例如,重组ＩＬ-1外周给药需1
Five IL-1 on brain function and its mechanism of action 1, pyrogenic effect: the earliest name of IL-1 ─ endogenous pyrogen can best reflect its pyrogenic effect. Injection of 30-50 ng / kg of this protein into rabbits provoked fever and later found that doses of IL-1 in the brain that cause maximum effects were found to be much smaller than doses that elicited the same effect by peripheral administration. For example, recombinant IL- 1 peripheral administration need 1